Mechanism
Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies.
Barbee SA, Estes PS, Cziko AM, Hillebrand J, Luedeman RA, Coller JM, Johnson N, Howlett IC, Geng C, Ueda R, Brand AH, Newbury
SF, Wilhelm JE, Levine RB, Nakamura A, Parker R, Ramaswami M.
Neuron. 2006 Dec 21;52(6):997-1009.
MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleolus and cytoplasm of rat myogenic cells.
Politz JC, Zhang F, Pederson T.
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):18957-62.
Induction of gene silencing by hairpin RNA expression in Tetrahymena thermophila reveals a second small RNA pathway.
Howard-Till RA, Yao MC.
Mol Cell Biol. 2006 Dec;26(23):8731-42.
RNA polymerase III transcribes human microRNAs.
Borchert GM, Lanier W, Davidson BL.
Nat Struct Mol Biol. 2006 Dec;13(12):1097-101.
Evidence that microRNAs are associated with translating messenger RNAs in human cells.
Maroney PA, Yu Y, Fisher J, Nilsen TW.
Nat Struct Mol Biol. 2006 Dec;13(12):1102-7.
Human let-7a miRNA blocks protein production on actively translating polyribosomes.
Nottrott S, Simard MJ, Richter JD.
Nat Struct Mol Biol. 2006 Dec;13(12):1108-14.
[Molecular mechanisms of RNA silencing by siRNA, miRNA and piRNA]
Nishida KM, Siomi MC.
Tanpakushitsu Kakusan Koso. 2006 Dec;51(16 Suppl):2450-5.
Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules.
Leung AK, Calabrese JM, Sharp PA.
Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18125-30.
miRNAs regulate miRNAs: coordinated transcriptional and post-transcriptional regulation.
Tuccoli A, Poliseno L, Rainaldi G.
Cell Cycle. 2006 Nov 1;5(21):2473-6.
[Biosynthesis mechanism of microRNAs]
Shibata S, Katahira J.
Tanpakushitsu Kakusan Koso. 2006 Nov;51(14 Suppl):2200-2.
Principles of micro-RNA production and maturation.
Zeng Y.
Oncogene. 2006 Oct 9;25(46):6156-62.
Principles and effects of microRNA-mediated post-transcriptional gene regulation.
Engels BM, Hutvagner G.
Oncogene. 2006 Oct 9;25(46):6163-9.
Mutation of siRNA results in thermodynamically unstable duplex which influences knockdown of dmrt1 by RNA interference.
Yao K, Lu H, Cheng H, Zhou R.
Front Biosci. 2006 Sep 1;11:2623-30.
Formation of GW bodies is a consequence of microRNA genesis.
Pauley KM, Eystathioy T, Jakymiw A, Hamel JC, Fritzler MJ, Chan EK.
EMBO Rep. 2006 Sep;7(9):904-10.
Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions.
Didiano D, Hobert O.
Nat Struct Mol Biol. 2006 Sep;13(9):849-51.
Extensive post-transcriptional regulation of microRNAs and its implications for cancer.
Thomson JM, Newman M, Parker JS, Morin-Kensicki EM, Wright T, Hammond SM.
Genes Dev. 2006 Aug 15;20(16):2202-7.
The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs.
Mendez Vidal C, Prahl M, Wiman KG.
FEBS Lett. 2006 Aug 7;580(18):4401-8.
Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?
Costa Y, Speed RM, Gautier P, Semple CA, Maratou K, Turner JM, Cooke HJ.
Hum Mol Genet. 2006 Aug 1;15(15):2324-34.
MicroRNA sequence motifs reveal asymmetry between the stem arms.
Gorodkin J, Havgaard JH, Enstero M, Sawera M, Jensen P, Ohman M, Fredholm M.
Comput Biol Chem. 2006 Aug;30(4):249-54.
[RNA binding proteins in the RNA interference phenomenon]
Kotel'nikov RN, Shpiz SG, Kalmykova AI, Gvozdev VA.
Mol Biol (Mosk). 2006 Jul-Aug;40(4):595-608.
Systematic discovery of the grammar of translational inhibition by RNA hairpins.
Jeffries C, Perkins DO, Jarstfer M.
J Theor Biol. 2006 Jul 21;241(2):205-15.
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes.
Behm-Ansmant I, Rehwinkel J, Doerks T, Stark A, Bork P, Izaurralde E.
Genes Dev. 2006 Jul 15;20(14):1885-98.
Comprehensive thermodynamic analysis of 3' double-nucleotide overhangs neighboring Watson-Crick terminal base pairs.
O'Toole AS, Miller S, Haines N, Zink MC, Serra MJ.
Nucleic Acids Res. 2006 Jul 4;34(11):3338-44.
Post-transcriptional regulation of microRNA expression.
Obernosterer G, Leuschner PJ, Alenius M, Martinez J.
RNA. 2006 Jul;12(7):1161-7.
microRNA-mediated silencing inside P-bodies.
Chan SP, Slack FJ.
RNA Biol. 2006 Jul;3(3):97-100.
P-bodies react to stress and nonsense.
Bruno I, Wilkinson MF.
Cell. 2006 Jun 16;125(6):1036-8.
Relief of microRNA-mediated translational repression in human cells subjected to stress.
Bhattacharyya SN, Habermacher R, Martine U, Closs EI, Filipowicz W.
Cell. 2006 Jun 16;125(6):1111-24.
Sequence variations of microRNAs in human cancer: alterations in predicted secondary structure do not affect processing.
Diederichs S, Haber DA.
Cancer Res. 2006 Jun 15;66(12):6097-104.
Rethinking the microprocessor.
Seitz H, Zamore PD.
Cell. 2006 Jun 2;125(5):827-9.
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex.
Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, Sohn SY, Cho Y, Zhang BT, Kim VN.
Cell. 2006 Jun 2;125(5):887-901.
A novel assay for viral microRNA function identifies a single nucleotide polymorphism that affects Drosha processing.
Gottwein E, Cai X, Cullen BR.
J Virol. 2006 Jun;80(11):5321-6.
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.
Chu CY, Rana TM.
PLoS Biol. 2006 Jun;4(7):e210.
Role of miRNA and miRNA processing factors in development and disease.
Conrad R, Barrier M, Ford LP.
Birth Defects Res C Embryo Today. 2006 Jun;78(2):107-17.
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways.
Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, Davis CR, Marion P, Salazar F, Kay MA.
Nature. 2006 May 25;441(7092):537-41.
Micro-RNA-like effects of complete intronic sequences.
Hill AE, Hong JS, Wen H, Teng L, McPherson DT, McPherson SA, Levasseur DN, Sorscher EJ.
Front Biosci. 2006 May 1;11:1998-2006.
Micromanagement: a role for microRNAs in mRNA stability.
Roush SF, Slack FJ.
ACS Chem Biol. 2006 Apr 25;1(3):132-4.
AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1.
Vaucheret H, Mallory AC, Bartel DP.
Mol Cell. 2006 Apr 7;22(1):129-36.
Hairpin RNA: a secondary structure of primary importance.
Svoboda P, Di Cara A.
Cell Mol Life Sci. 2006 Apr;63(7-8):901-8.
MicroRNA modulation of RNA-binding protein regulatory elements.
George AD, Tenenbaum SA.
RNA Biol. 2006 Apr;3(2):57-9.
Primate microRNAs miR-220 and miR-492 lie within processed pseudogenes.
Devor EJ.
J Hered. 2006 Mar-Apr;97(2):186-90.
MicroRNAs direct rapid deadenylation of mRNA.
Wu L, Fan J, Belasco JG.
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4034-9.
Lower expression of genes near microRNA in C. elegans germline.
Inaoka H, Fukuoka Y, Kohane IS.
BMC Bioinformatics. 2006 Mar 6;7:112.
Control of translation and mRNA degradation by miRNAs and siRNAs.
Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R.
Genes Dev. 2006 Mar 1;20(5):515-24.
A high-throughput approach for associating MicroRNAs with their activity conditions.
Zilberstein CB, Ziv-Ukelson M, Pinter RY, Yakhini Z.
J Comput Biol. 2006 Mar;13(2):245-66.
The chromatoid body of male germ cells: similarity with processing bodies and presence of Dicer and microRNA pathway components.
Kotaja N, Bhattacharyya SN, Jaskiewicz L, Kimmins S, Parvinen M, Filipowicz W, Sassone-Corsi P.
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2647-52.
Short RNAs repress translation after initiation in mammalian cells.
Petersen CP, Bordeleau ME, Pelletier J, Sharp PA.
Mol Cell. 2006 Feb 17;21(4):533-42.
The role of PACT in the RNA silencing pathway.
Lee Y, Hur I, Park SY, Kim YK, Suh MR, Kim VN.
EMBO J. 2006 Feb 8;25(3):522-32.
Rapid alteration of microRNA levels by histone deacetylase inhibition.
Scott GK, Mattie MD, Berger CE, Benz SC, Benz CC.
Cancer Res. 2006 Feb 1;66(3):1277-81.
GW bodies, microRNAs and the cell cycle.
Lian S, Jakymiw A, Eystathioy T, Hamel JC, Fritzler MJ, Chan EK.
Cell Cycle. 2006 Feb;5(3):242-5.
HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide.
Yang Z, Ebright YW, Yu B, Chen X.
Nucleic Acids Res. 2006 Jan 30;34(2):667-75.
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D Jr, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR 3rd, Mello
CC.
Cell. 2006 Jan 27;124(2):343-54.
Current perspectives in intronic micro RNAs (miRNAs).
Ying SY, Lin SL.
J Biomed Sci. 2006 Jan;13(1):5-15.
Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function.
Pang KC, Frith MC, Mattick JS.
Trends Genet. 2006 Jan;22(1):1-5.
Modulation of microRNA processing and expression through RNA editing by ADAR deaminases.
Yang W, Chendrimada TP, Wang Q, Higuchi M, Seeburg PH, Shiekhattar R, Nishikura K.
Nat Struct Mol Biol. 2006 Jan;13(1):13-21.
Drosha versus ADAR: wrangling over pri-miRNA.
O'Connell MA, Keegan LP.
Nat Struct Mol Biol. 2006 Jan;13(1):3-4.
Evidence that miRNAs are different from other RNAs.
Zhang BH, Pan XP, Cox SB, Cobb GP, Anderson TA.
Cell Mol Life Sci. 2006 Jan;63(2):246-54.
Conserved microRNA characteristics in mammals.
Saetrom P, Snove O, Nedland M, Grunfeld TB, Lin Y, Bass MB, Canon JR.
Oligonucleotides. 2006 Summer;16(2):115-44.
Small non-coding RNAs and genomic imprinting.
Royo H, Bortolin ML, Seitz H, Cavaille J.
Cytogenet Genome Res. 2006;113(1-4):99-108.
RNA editing of human microRNAs.
Blow MJ, Grocock RJ, van Dongen S, Enright AJ, Dicks E, Futreal PA, Wooster R, Stratton MR.
Genome Biol. 2006;7(4):R27.
Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi.
Snove O Jr, Rossi JJ.
Genome Biol. 2006;7(8):231.
Structure analysis of microRNA precursors.
Krol J, Krzyzosiak WJ.
Methods Mol Biol. 2006;342:19-32.
MicroRNA biogenesis: isolation and characterization of the microprocessor complex.
Gregory RI, Chendrimada TP, Shiekhattar R.
Methods Mol Biol. 2006;342:33-47.
Recognition and cleavage of primary microRNA transcripts.
Zeng Y, Cullen BR.
Methods Mol Biol. 2006;342:49-56.
MicroRNAs and messenger RNA turnover.
Chekanova JA, Belostotsky DA.
Methods Mol Biol. 2006;342:73-85.
Identification of messenger RNAs and microRNAs associated with fragile X mental retardation protein.
Duan R, Jin P.
Methods Mol Biol. 2006;342:267-76.
Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing.
Yeom KH, Lee Y, Han J, Suh MR, Kim VN.
Nucleic Acids Res. 2006;34(16):4622-9.
Exportin-5 orthologues are functionally divergent among species.
Shibata S, Sasaki M, Miki T, Shimamoto A, Furuichi Y, Katahira J, Yoneda Y.
Nucleic Acids Res. 2006;34(17):4711-21.
Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells.
Schmitter D, Filkowski J, Sewer A, Pillai RS, Oakeley EJ, Zavolan M, Svoboda P, Filipowicz W.
Nucleic Acids Res. 2006;34(17):4801-15.
Function and localization of microRNAs in mammalian cells.
Leung AK, Sharp PA.
Cold Spring Harb Symp Quant Biol. 2006;71:29-38.
Drosha in primary microRNA processing.
Lee Y, Han J, Yeom KH, Jin H, Kim VN.
Cold Spring Harb Symp Quant Biol. 2006;71:51-7.
Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs.
Lund E, Dahlberg JE.
Cold Spring Harb Symp Quant Biol. 2006;71:59-66.
The Argonautes.
Joshua-Tor L.
Cold Spring Harb Symp Quant Biol. 2006;71:67-72.
Structural biology of RNA silencing and its functional implications.
Patel DJ, Ma JB, Yuan YR, Ye K, Pei Y, Kuryavyi V, Malinina L, Meister G, Tuschl T.
Cold Spring Harb Symp Quant Biol. 2006;71:81-93.
The Caenorhabditis elegans Argonautes ALG-1 and ALG-2: almost identical yet different.
Tops BB, Plasterk RH, Ketting RF.
Cold Spring Harb Symp Quant Biol. 2006;71:189-94.
MicroRNA function and mechanism: insights from zebra fish.
Schier AF, Giraldez AJ.
Cold Spring Harb Symp Quant Biol. 2006;71:195-203.
How does RNA editing affect dsRNA-mediated gene silencing?
Bass BL.
Cold Spring Harb Symp Quant Biol. 2006;71:285-92.
Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells.
Bhattacharyya SN, Habermacher R, Martine U, Closs EI, Filipowicz W.
Cold Spring Harb Symp Quant Biol. 2006;71:513-21.
MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay.
Behm-Ansmant I, Rehwinkel J, Izaurralde E.
Cold Spring Harb Symp Quant Biol. 2006;71:523-30.
MicroRNAs, mRNAs, and translation.
Maroney PA, Yu Y, Nilsen TW.
Cold Spring Harb Symp Quant Biol. 2006;71:531-5.