Mechanism
Transcription and processing of human microRNA precursors.
Cullen BR.
Mol Cell. 2004 Dec 22;16(6):861-5.
The Drosha-DGCR8 complex in primary microRNA processing.
Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN.
Genes Dev. 2004 Dec 15;18(24):3016-27.
The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.
Landthaler M, Yalcin A, Tuschl T.
Curr Biol. 2004 Dec 14;14(23):2162-7.
Substrate requirements for let-7 function in the developing zebrafish embryo.
Kloosterman WP, Wienholds E, Ketting RF, Plasterk RH.
Nucleic Acids Res. 2004 Dec 7;32(21):6284-91.
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs.
Cai X, Hagedorn CH, Cullen BR.
RNA. 2004 Dec;10(12):1957-66.
Architecture of a validated microRNA::target interaction.
Vella MC, Reinert K, Slack FJ.
Chem Biol. 2004 Dec;11(12):1619-23.
Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences.
Bonnet E, Wuyts J, Rouze P, Van de Peer Y.
Bioinformatics. 2004 Nov 22;20(17):2911-7.
mRNA turnover meets RNA interference.
Belostotsky D.
Mol Cell. 2004 Nov 19;16(4):498-500.
FMRP and its target RNAs: fishing for the specificity.
Veneri M, Zalfa F, Bagni C.
Neuroreport. 2004 Nov 15;15(16):2447-50.
The Microprocessor complex mediates the genesis of microRNAs.
Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R.
Nature. 2004 Nov 11;432(7014):235-40.
Processing of primary microRNAs by the Microprocessor complex.
Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ.
Nature. 2004 Nov 11;432(7014):231-5.
Intron-derived microRNAs--fine tuning of gene functions.
Ying SY, Lin SL.
Gene. 2004 Nov 10;342(1):25-8.
Uridine addition after microRNA-directed cleavage.
Shen B, Goodman HM.
Science. 2004 Nov 5;306(5698):997.
Diversity of antisense regulation in eukaryotes: multiple mechanisms, emerging patterns.
Munroe SH.
J Cell Biochem. 2004 Nov 1;93(4):664-71.
MicroRNA genes are transcribed by RNA polymerase II.
Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH, Kim VN.
EMBO J. 2004 Oct 13;23(20):4051-60.
Structural features of microRNA (miRNA) precursors and their relevance to miRNA biogenesis and small interfering RNA/short hairpin
RNA design.
Krol J, Sobczak K, Wilczynska U, Drath M, Jasinska A, Kaczynska D, Krzyzosiak WJ.
J Biol Chem. 2004 Oct 1;279(40):42230-9.
Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis.
Pillai RS, Artus CG, Filipowicz W.
RNA. 2004 Oct;10(10):1518-25.
Trans-splicing and polyadenylation of let-7 microRNA primary transcripts.
Bracht J, Hunter S, Eachus R, Weeks P, Pasquinelli AE.
RNA. 2004 Oct;10(10):1586-94.
Molecular mechanisms of translational control.
Gebauer F, Hentze MW.
Nat Rev Mol Cell Biol. 2004 Oct;5(10):827-35.
Imprinted small RNA genes.
Seitz H, Royo H, Lin SP, Youngson N, Ferguson-Smith AC, Cavaille J.
Biol Chem. 2004 Oct;385(10):905-11.
A population-based statistical approach identifies parameters characteristic of human microRNA-mRNA interactions.
Smalheiser NR, Torvik VI.
BMC Bioinformatics. 2004 Sep 28;5:139.
Structural requirements for pre-microRNA binding and nuclear export by Exportin 5.
Zeng Y, Cullen BR.
Nucleic Acids Res. 2004 Sep 8;32(16):4776-85.
Argonaute2 is the catalytic engine of mammalian RNAi.
Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon GJ.
Science. 2004 Sep 3;305(5689):1437-41.
Molecular biology. Argonaute journeys into the heart of RISC.
Sontheimer EJ, Carthew RW.
Science. 2004 Sep 3;305(5689):1409-10.
A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain.
Seitz H, Royo H, Bortolin ML, Lin SP, Ferguson-Smith AC, Cavaille J.
Genome Res. 2004 Sep;14(9):1741-8.
Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification.
Ohler U, Yekta S, Lim LP, Bartel DP, Burge CB.
RNA. 2004 Sep;10(9):1309-22.
Common logic of transcription factor and microRNA action.
Hobert O.
Trends Biochem Sci. 2004 Sep;29(9):462-8.
Class III HD-Zip gene regulation, the golden fleece of ARGONAUTE activity?
Bowman JL.
Bioessays. 2004 Sep;26(9):938-42.
RNA editing of a miRNA precursor.
Luciano DJ, Mirsky H, Vendetti NJ, Maas S.
RNA. 2004 Aug;10(8):1174-7.
The long hand of the small RNAs reaches into several levels of gene regulation.
Nolan T, Cogoni C.
Biochem Cell Biol. 2004 Aug;82(4):472-81.
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T.
Mol Cell. 2004 Jul 23;15(2):185-97.
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways.
Okamura K, Ishizuka A, Siomi H, Siomi MC.
Genes Dev. 2004 Jul 15;18(14):1655-66.
Single processing center models for human Dicer and bacterial RNase III.
Zhang H, Kolb FA, Jaskiewicz L, Westhof E, Filipowicz W.
Cell. 2004 Jul 9;118(1):57-68.
miRNAs on the move: miRNA biogenesis and the RNAi machinery.
Murchison EP, Hannon GJ.
Curr Opin Cell Biol. 2004 Jun;16(3):223-9.
Molecular evolution of a microRNA cluster.
Tanzer A, Stadler PF.
J Mol Biol. 2004 May 28;339(2):327-35.
MicroRNA-directed cleavage of HOXB8 mRNA.
Yekta S, Shih IH, Bartel DP.
Science. 2004 Apr 23;304(5670):594-6.
Dicers at RISC; the mechanism of RNAi.
Tijsterman M, Plasterk RH.
Cell. 2004 Apr 2;117(1):1-3.
Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.
Lee YS, Nakahara K, Pham JW, Kim K, He Z, Sontheimer EJ, Carthew RW.
Cell. 2004 Apr 2;117(1):69-81.
Sequence-specific inhibition of small RNA function.
Hutvagner G, Simard MJ, Mello CC, Zamore PD.
PLoS Biol. 2004 Apr;2(4):E98.
[Advances in the molecular mechanism of RNA interference]
He GP, Zhang SZ.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Apr;21(2):161-5.
MicroRNA precursors in motion: exportin-5 mediates their nuclear export.
Kim VN.
Trends Cell Biol. 2004 Apr;14(4):156-9.
Genetic analysis of RNA-mediated transcriptional gene silencing.
Matzke M, Aufsatz W, Kanno T, Daxinger L, Papp I, Mette MF, Matzke AJ.
Biochim Biophys Acta. 2004 Mar 15;1677(1-3):129-41.
Specificity of microRNA target selection in translational repression.
Doench JG, Sharp PA.
Genes Dev. 2004 Mar 1;18(5):504-11.
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.
Meister G, Landthaler M, Dorsett Y, Tuschl T.
RNA. 2004 Mar;10(3):544-50.
RNase III enzymes and the initiation of gene silencing.
Carmell MA, Hannon GJ.
Nat Struct Mol Biol. 2004 Mar;11(3):214-8.
Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway.
Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST.
Nat Neurosci. 2004 Feb;7(2):113-7.
Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes.
Lai EC, Wiel C, Rubin GM.
RNA. 2004 Feb;10(2):171-5.
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs.
Bohnsack MT, Czaplinski K, Gorlich D.
RNA. 2004 Feb;10(2):185-91.
Structural aspects of microRNA biogenesis.
Krol J, Krzyzosiak WJ.
IUBMB Life. 2004 Feb;56(2):95-100.
The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR.
Vella MC, Choi EY, Lin SY, Reinert K, Slack FJ.
Genes Dev. 2004 Jan 15;18(2):132-7.
Nuclear export of microRNA precursors.
Lund E, Guttinger S, Calado A, Dahlberg JE, Kutay U.
Science. 2004 Jan 2;303(5654):95-8.
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.
Yi R, Qin Y, Macara IG, Cullen BR.
Genes Dev. 2003 Dec 15;17(24):3011-6.
Human let-7 stem-loop precursors harbor features of RNase III cleavage products.
Basyuk E, Suavet F, Doglio A, Bordonne R, Bertrand E.
Nucleic Acids Res. 2003 Nov 15;31(22):6593-7.
Asymmetry in the assembly of the RNAi enzyme complex.
Schwarz DS, Hutvagner G, Du T, Xu Z, Aronin N, Zamore PD.
Cell. 2003 Oct 17;115(2):199-208.
Functional siRNAs and miRNAs exhibit strand bias.
Khvorova A, Reynolds A, Jayasena SD.
Cell. 2003 Oct 17;115(2):209-16.
The nuclear RNase III Drosha initiates microRNA processing.
Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Radmark O, Kim S, Kim VN.
Nature. 2003 Sep 25;425(6956):415-9.
Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing.
Schramke V, Allshire R.
Science. 2003 Aug 22;301(5636):1069-74.
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms.
Zeng Y, Yi R, Cullen BR.
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9779-84.
The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its
promoter.
Johnson SM, Lin SY, Slack FJ.
Dev Biol. 2003 Jul 15;259(2):364-79.
Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene.
Seitz H, Youngson N, Lin SP, Dalbert S, Paulsen M, Bachellerie JP, Ferguson-Smith AC, Cavaille J.
Nat Genet. 2003 Jul;34(3):261-2.
The RNA binding protein FMRP: new connections and missing links.
Schaeffer C, Beaulande M, Ehresmann C, Ehresmann B, Moine H.
Biol Cell. 2003 May-Jun;95(3-4):221-8.
siRNAs can function as miRNAs.
Doench JG, Petersen CP, Sharp PA.
Genes Dev. 2003 Feb 15;17(4):438-42.
Germline transmission of RNAi in mice.
Carmell MA, Zhang L, Conklin DS, Hannon GJ, Rosenquist TA.
Nat Struct Biol. 2003 Feb;10(2):91-2.
EST analyses predict the existence of a population of chimeric microRNA precursor-mRNA transcripts expressed in normal human and
mouse tissues.
Smalheiser NR.
Genome Biol. 2003;4(7):403.
Fragile X-related protein and VIG associate with the RNA interference machinery.
Caudy AA, Myers M, Hannon GJ, Hammond SM.
Genes Dev. 2002 Oct 1;16(19):2491-6.
A microRNA in a multiple-turnover RNAi enzyme complex.
Hutvagner G, Zamore PD.
Science. 2002 Sep 20;297(5589):2056-60.
Small RNAs correspond to centromere heterochromatic repeats.
Reinhart BJ, Bartel DP.
Science. 2002 Sep 13;297(5588):1831.
MicroRNA maturation: stepwise processing and subcellular localization.
Lee Y, Jeon K, Lee JT, Kim S, Kim VN.
EMBO J. 2002 Sep 2;21(17):4663-70.
Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells.
Zeng Y, Wagner EJ, Cullen BR.
Mol Cell. 2002 Jun;9(6):1327-33.
Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation.
Lai EC.
Nat Genet. 2002 Apr;30(4):363-4.
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs.
Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G.
Genes Dev. 2002 Mar 15;16(6):720-8.