June 2006
Developmental
Effective gene therapy in an authentic model of Tay-Sachs-related diseases.
Cachon-Gonzalez MB, Wang SZ, Lynch A, Ziegler R, Cheng SH, Cox TM.
Proc Natl Acad Sci U S A. 2006 Jun 26
ADHD
Association Between Alpha-2a-adrenergic Receptor Gene and ADHD Inattentive Type.
Schmitz M, Denardin D, Silva TL, Pianca T, Roman T, Hutz MH, Faraone SV, Rohde LA.
Biol Psychiatry. 2006 Jun 23
Association between DRD4 Gene and Performance of Children with ADHD in a Test of Sustained Attention.
Kieling C, Roman T, Doyle AE, Hutz MH, Rohde LA.
Biol Psychiatry. 2006 Jun 14
Creutzfeldt-Jakob
Dissociation of pathological and molecular phenotype of variant Creutzfeldt-Jakob disease in transgenic human prion protein
129 heterozygous mice.
Asante EA, Linehan JM, Gowland I, Joiner S, Fox K, Cooper S, Osiguwa O, Gorry M, Welch J, Houghton R, Desbruslais M, Brandner S,
Wadsworth JD, Collinge J.
Proc Natl Acad Sci U S A. 2006 Jun 29
Huntington's
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S,
Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR.
Cell. 2006 Jun 16;125(6):1179-91.
Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of
Huntington's disease.
McBride JL, Ramaswamy S, Gasmi M, Bartus RT, Herzog CD, Brandon EP, Zhou L, Pitzer MR, Berry-Kravis EM, Kordower JH.
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9345-50.
Alzheimer's
Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: Long-term effects and safety.
Okura Y, Miyakoshi A, Kohyama K, Park IK, Staufenbiel M, Matsumoto Y.
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9619-24.
An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice.
Le Corre S, Klafki HW, Plesnila N, Hubinger G, Obermeier A, Sahagun H, Monse B, Seneci P, Lewis J, Eriksen J, Zehr C, Yue M,
McGowan E, Dickson DW, Hutton M, Roder HM.
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9673-8.
Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease.
Stoub TR, de Toledo-Morrell L, Stebbins GT, Leurgans S, Bennett DA, Shah RC.
Proc Natl Acad Sci U S A. 2006 Jun 19
Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.
McLaurin J, Kierstead ME, Brown ME, Hawkes CA, Lambermon MH, Phinney AL, Darabie AA, Cousins JE, French JE, Lan MF, Chen F,
Wong SS, Mount HT, Fraser PE, Westaway D, George-Hyslop PS.
Nat Med. 2006 Jun 11
Med-Psych
Acute Depressed Mood as a Trigger of Acute Coronary Syndromes.
Steptoe A, Strike PC, Perkins-Porras L, McEwan JR, Whitehead DL.
Biol Psychiatry. 2006 Jun 13
Substance
Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter.
Chen R, Tilley MR, Wei H, Zhou F, Zhou FM, Ching S, Quan N, Stephens RL, Hill ER, Nottoli T, Han DD, Gu HH.
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9333-8.
Schizophrenia
Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIalpha gene (PIP5K2A)
with schizophrenia.
Schwab SG, Knapp M, Sklar P, Eckstein GN, Sewekow C, Borrmann-Hassenbach M, Albus M, Becker T, Hallmayer JF, Lerer B, Maier W,
Wildenauer DB.
Mol Psychiatry. 2006 Jun 27
Tryptophan Hydroxylase-1 Gene Variants Associated with Schizophrenia.
Zaboli G, Jonsson EG, Gizatullin R, Asberg M, Leopardi R.
Biol Psychiatry. 2006 Jun 23
Microtubule Stabilizer Ameliorates Synaptic Function and Behavior in a Mouse Model for Schizophrenia.
Andrieux A, Salin P, Schweitzer A, Begou M, Pachoud B, Brun P, Gory-Faure S, Kujala P, Suaud-Chagny MF, Hofle G, Job D.
Biol Psychiatry. 2006 Jun 23
Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder?
Powell CM, Miyakawa T.
Biol Psychiatry. 2006 Jun 15;59(12):1198-207.
Altered neuregulin 1-erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia.
Hahn CG, Wang HY, Cho DS, Talbot K, Gur RE, Berrettini WH, Bakshi K, Kamins J, Borgmann-Winter KE, Siegel SJ, Gallop RJ, Arnold
SE.
Nat Med. 2006 Jun 11
Bipolar
Differential Expression of Disrupted-in-Schizophrenia (DISC1) in Bipolar Disorder.
Maeda K, Nwulia E, Chang J, Balkissoon R, Ishizuka K, Chen H, Zandi P, McInnis MG, Sawa A.
Biol Psychiatry. 2006 Jun 27
Nested Association Between Genetic Variation in Tryptophan Hydroxylase II, Bipolar Affective Disorder, and Suicide Attempts.
Lopez VA, Detera-Wadleigh S, Cardona I, Kassem L; The National Institute of Mental Health Genetics Initiative Bipolar Disorder
Consortium; McMahon FJ.
Biol Psychiatry. 2006 Jun 23
Anxiety
Panic-prone state induced in rats with GABA dysfunction in the dorsomedial hypothalamus is mediated by NMDA receptors.
Johnson PL, Shekhar A.
J Neurosci. 2006 Jun 28;26(26):7093-104.
Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in
metabotropic glutamate receptor 7-deficient mice.
Callaerts-Vegh Z, Beckers T, Ball SM, Baeyens F, Callaerts PF, F Cryan J, Molnar E, D'Hooge R.
J Neurosci. 2006 Jun 14;26(24):6573-82.
Eating
The Prevalence and Correlates of Eating Disorders in the National Comorbidity Survey Replication.
Hudson JI, Hiripi E, Pope HG Jr, Kessler RC.
Biol Psychiatry. 2006 Jun 30
Fluoxetine after weight restoration in anorexia nervosa: a randomized controlled trial.
Walsh BT, Kaplan AS, Attia E, Olmsted M, Parides M, Carter JC, Pike KM, Devlin MJ, Woodside B, Roberto CA, Rockert W.
JAMA. 2006 Jun 14;295(22):2605-12.
Sleep
Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled
trial.
Sivertsen B, Omvik S, Pallesen S, Bjorvatn B, Havik OE, Kvale G, Nielsen GH, Nordhus IH.
JAMA. 2006 Jun 28;295(24):2851-8.
Child
MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a
meta-analysis.
Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW, Moffitt TE.
Mol Psychiatry. 2006 Jun 27
Geriatrics
A controlled trial of homocysteine lowering and cognitive performance.
McMahon JA, Green TJ, Skeaff CM, Knight RG, Mann JI, Williams SM.
N Engl J Med. 2006 Jun 29;354(26):2764-72.
Psychology
Social modulation of pain as evidence for empathy in mice.
Langford DJ, Crager SE, Shehzad Z, Smith SB, Sotocinal SG, Levenstadt JS, Chanda ML, Levitin DJ, Mogil JS.
Science. 2006 Jun 30;312(5782):1967-70.
Optimal decision making and the anterior cingulate cortex.
Kennerley SW, Walton ME, Behrens TE, Buckley MJ, Rushworth MF.
Nat Neurosci. 2006 Jun 18
Broca's Area and the Hierarchical Organization of Human Behavior.
Koechlin E, Jubault T.
Neuron. 2006 Jun 15;50(6):963-74.
The mellow years?: neural basis of improving emotional stability over age.
Williams LM, Brown KJ, Palmer D, Liddell BJ, Kemp AH, Olivieri G, Peduto A, Gordon E.
J Neurosci. 2006 Jun 14;26(24):6422-30.
Biology
A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline.
Vagin VV, Sigova A, Li C, Seitz H, Gvozdev V, Zamore PD.
Science. 2006 Jun 29
Layer acquisition by cortical GABAergic interneurons is independent of Reelin signaling.
Pla R, Borrell V, Flames N, Marin O.
J Neurosci. 2006 Jun 28;26(26):6924-34.
RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual
behaviors.
Musatov S, Chen W, Pfaff DW, Kaplitt MG, Ogawa S.
Proc Natl Acad Sci U S A. 2006 Jun 27
JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS.
Koh K, Zheng X, Sehgal A.
Science. 2006 Jun 23;312(5781):1809-12.
Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress.
Bhattacharyya SN, Habermacher R, Martine U, Closs EI, Filipowicz W.
Cell. 2006 Jun 16;125(6):1111-24.
A Review of Disrupted-in-Schizophrenia-1 (disc1): Neurodevelopment, Cognition, and Mental Conditions.
Ishizuka K, Paek M, Kamiyaand A, Sawa A.
Biol Psychiatry. 2006 Jun 15;59(12):1189-97.
Hippocampal neurogenesis: regulation by stress and antidepressants.
Dranovsky A, Hen R.
Biol Psychiatry. 2006 Jun 15;59(12):1136-43.