July 2006
Autism
Stereological analysis of amygdala neuron number in autism.
Schumann CM, Amaral DG.
J Neurosci. 2006 Jul 19;26(29):7674-9.
Dementia
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
Cruts M, Gijselinck I, van der Zee J, Engelborghs S, Wils H, Pirici D, Rademakers R, Vandenberghe R, Dermaut B, Martin JJ, van Duijn C,
Peeters K, Sciot R, Santens P, De Pooter T, Mattheijssens M, Van den Broeck M, Cuijt I, Vennekens K, De Deyn PP, Kumar-Singh S, Van
Broeckhoven C.
Nature. 2006 Jul 16
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.
Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S,
Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Berger Z, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R,
McGowan E, Mann D, Boeve B, Feldman H, Hutton M.
Nature. 2006 Jul 16
Substance
Counseling plus buprenorphine-naloxone maintenance therapy for opioid dependence.
Fiellin DA, Pantalon MV, Chawarski MC, Moore BA, Sullivan LE, O'Connor PG, Schottenfeld RS.
N Engl J Med. 2006 Jul 27;355(4):365-74.
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for
smoking cessation: a randomized controlled trial.
Gonzales D, Rennard SI, Nides M, Oncken C, Azoulay S, Billing CB, Watsky EJ, Gong J, Williams KE, Reeves KR; Varenicline Phase 3
Study Group.
JAMA. 2006 Jul 5;296(1):47-55.
Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release
bupropion for smoking cessation: a randomized controlled trial.
Jorenby DE, Hays JT, Rigotti NA, Azoulay S, Watsky EJ, Williams KE, Billing CB, Gong J, Reeves KR; Varenicline Phase 3 Study Group.
JAMA. 2006 Jul 5;296(1):56-63.
Effect of maintenance therapy with varenicline on smoking cessation: a randomized controlled trial.
Tonstad S, Tonnesen P, Hajek P, Williams KE, Billing CB, Reeves KR; Varenicline Phase 3 Study Group.
JAMA. 2006 Jul 5;296(1):64-71.
Schizophrenia
Making the Case for a Candidate Vulnerability Gene in Schizophrenia: Convergent Evidence for Regulator of G-Protein
Signaling 4 (RGS4).
Levitt P, Ebert P, Mirnics K, Nimgaonkar VL, Lewis DA.
Biol Psychiatry. 2006 Jul 21
The genetics and biology of disc1-an emerging role in psychosis and cognition.
Porteous DJ, Thomson P, Brandon NJ, Millar JK.
Biol Psychiatry. 2006 Jul 15;60(2):123-31.
Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and
bipolar disorder.
Pickard BS, Malloy MP, Christoforou A, Thomson PA, Evans KL, Morris SW, Hampson M, Porteous DJ, Blackwood DH, Muir WJ.
Mol Psychiatry. 2006 Jul 4
Childhood-Onset Schizophrenia: A Double-Blind, Randomized Clozapine-Olanzapine Comparison.
Shaw P, Sporn A, Gogtay N, Overman GP, Greenstein D, Gochman P, Tossell JW, Lenane M, Rapoport JL.
Arch Gen Psychiatry. 2006 Jul;63(7):721-730.
Depression
A Comparison of Mirtazapine and Nortriptyline Following Two Consecutive Failed Medication Treatments for Depressed
Outpatients: A STAR*D Report.
Fava M, Rush AJ, Wisniewski SR, Nierenberg AA, Alpert JE, McGrath PJ, Thase ME, Warden D, Biggs M, Luther JF, Niederehe G, Ritz L,
Trivedi MH.
Am J Psychiatry. 2006 Jul;163(7):1161-72.
Anxiety
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.
Weisstaub NV, Zhou M, Lira A, Lambe E, Gonzalez-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS,
Morelli E, Mann JJ, Toth M, Aghajanian G, Sealfon SC, Hen R, Gingrich JA.
Science. 2006 Jul 28;313(5786):536-40.
Glutamate Transporter Gene SLC1A1 Associated With Obsessive-compulsive Disorder.
Arnold PD, Sicard T, Burroughs E, Richter MA, Kennedy JL.
Arch Gen Psychiatry. 2006 Jul;63(7):769-776.
Association Testing of the Positional and Functional Candidate Gene SLC1A1/EAAC1 in Early-Onset Obsessive-compulsive
Disorder.
Dickel DE, Veenstra-Vanderweele J, Cox NJ, Wu X, Fischer DJ, Van Etten-Lee M, Himle JA, Leventhal BL, Cook EH Jr, Hanna GL.
Arch Gen Psychiatry. 2006 Jul;63(7):778-785.
Eating
Association Between Obesity and Psychiatric Disorders in the US Adult Population.
Simon GE, Von Korff M, Saunders K, Miglioretti DL, Crane PK, van Belle G, Kessler RC.
Arch Gen Psychiatry. 2006 Jul;63(7):824-830.
Personality
Two-Year Randomized Controlled Trial and Follow-up of Dialectical Behavior Therapy vs Therapy by Experts for Suicidal
Behaviors and Borderline Personality Disorder.
Linehan MM, Comtois KA, Murray AM, Brown MZ, Gallop RJ, Heard HL, Korslund KE, Tutek DA, Reynolds SK, Lindenboim N.
Arch Gen Psychiatry. 2006 Jul;63(7):757-766.
Psychology
Theories and measures of consciousness: An extended framework.
Seth AK, Izhikevich E, Reeke GN, Edelman GM.
Proc Natl Acad Sci U S A. 2006 Jul 3
Anterior cingulate cortex responds differentially to expectancy violation and social rejection.
Somerville LH, Heatherton TF, Kelley WM.
Nat Neurosci. 2006 Jul 2
Biology
Knocking down Disease with siRNAs.
Dykxhoorn DM, Lieberman J.
Cell. 2006 Jul 28;126(2):231-5.
A genomic code for nucleosome positioning.
Segal E, Fondufe-Mittendorf Y, Chen L, Thastrom A, Field Y, Moore IK, Wang JP, Widom J.
Nature. 2006 Jul 19
Heritable and stable gene knockdown in rats.
Dann CT, Alvarado AL, Hammer RE, Garbers DL.
Proc Natl Acad Sci U S A. 2006 Jul 14
Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.
Alvarez-Dolado M, Calcagnotto ME, Karkar KM, Southwell DG, Jones-Davis DM, Estrada RC, Rubenstein JL, Alvarez-Buylla A, Baraban
SC.
J Neurosci. 2006 Jul 12;26(28):7380-9.
A network of protein interactions determines polyglutamine toxicity.
Duennwald ML, Jagadish S, Giorgini F, Muchowski PJ, Lindquist S.
Proc Natl Acad Sci U S A. 2006 Jul 10
Flanking sequences profoundly alter polyglutamine toxicity in yeast.
Duennwald ML, Jagadish S, Muchowski PJ, Lindquist S.
Proc Natl Acad Sci U S A. 2006 Jul 10
Genome-wide genetic association of complex traits in heterogeneous stock mice.
Valdar W, Solberg LC, Gauguier D, Burnett S, Klenerman P, Cookson1 WO, Taylor MS, Rawlins JN, Mott R, Flint J.
Nat Genet. 2006 Jul 9
Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron
Degeneration.
Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia
W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC.
Neuron. 2006 Jul 6;51(1):29-42.
Computational prediction of methylation status in human genomic sequences.
Das R, Dimitrova N, Xuan Z, Rollins RA, Haghighi F, Edwards JR, Ju J, Bestor TH, Zhang MQ.
Proc Natl Acad Sci U S A. 2006 Jul 3